Biochemical investigations on a transplantable rat leukemia. I. Transplantability of strains 302 and J.

Two strains of lymphatic leukemia, J and 302, have been maintained through hundreds of successive intraperitoneal injections of spleen tissue from leukemic donors. The two strains appeared to be similar pathologically, but were chemically dissimi lar. The J leukemia had white cell counts of 500,000-1,000,000 cu. mm. with enlarged spleen and no jaundice. The 302 strain had markedly enlarged liver, slightly enlarged spleen, and easily observable jaundice terminally. The ease of maintenance of the two strains of leukemia provides an opportunity for biochemical, metabolic, nutritional and chemotherapeutic studies.